Monday, 15 October, 2018

Houston doctor jointly awarded Nobel Prize in Medicine

US Japanese Immunologists Win Nobel For Revolutionary Cancer Treatment James P Allison and Tasuku Honjo win Nobel prize for medicine
Doris Mccormick | 03 October, 2018, 19:16

The 2018 Nobel Prize for Medicine or Physiology has been jointly awarded to United States and Japanese immunologists James P Allison and Tasuku Honjo. Research by Allison at the University of Texas in the USA and Honjo at Japan's Kyoto University explored how the body's immune system can be harnessed to attack cancer cells by releasing the brakes on immune cells.

Honjo, a professor in the Department of Immunology and Genomic Medicine at Japan's Kyoto University Graduate School of Medicine, discovered PD-1 on the surface of immune cells in 1992 and later demonstrated that the protein inhibited immune response.

The Nobel committee said the pair's research - which harnesses the body's immune system to attack cancer cells - amounted to a "landmark in our fight against cancer".

In 2014, Allison and Honjo received the first "Tang Prize for Biopharmaceutical Science" for their research in cancer immunotherapy, a type of treatment that allows for the immune system to fight cancer effectively.

The research honored with today's Nobel Prize in Medicine paid off for at least one very famous patient: former USA president Jimmy Carter.

Mr Carter was diagnosed in 2015 with the skin cancer melanoma, which had spread to his brain. A year later, he announced he no longer needed treatment. It said Allison and Honjo's work "revolutionized cancer treatment and has fundamentally changed the way we view how cancer can be managed". "So that this immune therapy will save more cancer patients than ever", he told reporters at the University of Kyoto where he is based.

The citation for this year's Nobel Prize in Medicine says the two honorees developed therapies for treating cancer. That award from Keio University recognizes researchers who have made an outstanding contribution to medicine or the life sciences.

KYOTO-Tasuku Honjo credits his lifelong natural curiosity for his achievements that were capped with being named October 1 co-winner of this year's Nobel Prize in Physiology or Medicine.

Rockies edge Cubs in 13-inning, wild-card classic
Lester is no stranger to October baseball, as he's set to make his 22nd postseason start and his second in the Wild Card game. He ran for his star first baseman with the speedy Gore, who promptly swiped second. "I think this is a classic", Black said.


Hoffenheim 1 Manchester City 2: Silva settles it late on
Sergio Aguero is a doubt for City's trip to Hoffenheim after limping out of the weekend win over Brighton with a foot injury.


Dodgers top Rockies 5-2 for 6th straight NL West title
Nolan Arenado hit two home runs and scored three while David Dahl hit a home run and drove in three more. The Atlanta Braves, L.A.'s Division Series opponent, with only two less wins.


Both Allison and Honjo discovered distinct proteins that were responsible for blocking the immune response: CTLA-4 and PD-1. Even if antigens are injected to activate the immune system, the PD-1 protein works to suppress immune function.

Why did this work win the Nobel prize?

"After many years of resistance, I think the cancer field has begun to accept immunotherapy now as the fourth pillar-along with radiation, surgery and chemotherapy-of cancer therapy".

Their discoveries have created a billion-dollar market for new cancer medicines, . especially offering new options for patients fighting against melanoma, lung and bladder cancers.

Mike Lazaridis (DEng '00), Principal of Quantum Valley Investments® and University of Waterloo Chancellor Emeritus " Donna Strickland exemplifies research excellence at Waterloo.

The Royal Swedish Academy of Sciences has awarded the 2018 Nobel Prize in Chemistry 2018 with one half to Frances H Arnold and the other half jointly to George P Smith and Sir Gregory P Winter for their work in evolution and phages.

"He told me, 'Thanks to you I can play golf again.' ..." It's a great, emotional privilege to meet cancer patients who've been successfully treated with immune checkpoint blockade.

Allison's ongoing leadership at MD Anderson focuses on improving knowledge of how these drugs work to extend the benefits of immunotherapy to more patients with more types of cancer.

Dr Arnold of the California Institute of Technology was awarded half the prize for conducting the first directed evolution of enzymes, leading to more environmentally friendly manufacturing of chemicals, including drugs, and in the production of renewable fuels.

Recommended

  • LAPD Busts Burglary Ring That Targeted Celebs Like Rihanna And Yasiel Puig

    Police said the victims were chosen when their social media postings and schedules indicated they would be away from home. More recently, there have also been reports that rappers Wiz Khalifa and Post Malone were hit by thieves.
    Queues for Theresa May speech are bigger than Boris Johnson's

    Queues for Theresa May speech are bigger than Boris Johnson's

    Britain's Prime Minister Theresa May walks to the Conservative Party Conference in Birmingham , Britain September 30, 2018. Johnson's 35-minute address ended with a standing ovation and rapturous applause.
    VENOM: Tom Hardy Gets Intense On The Red Carpet

    VENOM: Tom Hardy Gets Intense On The Red Carpet

    "[My favorite scenes to film] were scenes that aren't in this movie", Hardy told ComicsExplained . However, if Venom is a big enough success, we could see fans asking to see the missing footage.
  • Mourinho told Man Utd players: Play for the crest

    Mourinho told Man Utd players: Play for the crest

    Most of United's players finished the game with their hands on their hips after another one-dimensional and ponderous performance. United won their first match of the Champions League group stage against Young Boys, but had to make do with a point today.
    Here’s what we know about the FBI investigation into Brett Kavanaugh

    Here’s what we know about the FBI investigation into Brett Kavanaugh

    Kavanaugh first testified for his confirmation hearing before lawmakers on the committee almost a month ago - September 4. McConnell has said the Senate will be voting on Kavanaugh this week. "I just hope that we find fact", Flake said.

    Mourinho - United have 'desire to win, fear to lose'

    Mourinho is understood to have vented his anger about the poor planning as the bus crawled along the short route to Old Trafford. Against Valencia , he was one of United's most impressive players, though in fairness, there wasn't much competition.
  • Steven Spielberg's 'West Side Story' to Star Ansel Elgort as Tony

    Steven Spielberg's 'West Side Story' to Star Ansel Elgort as Tony

    Yet, Elgort's onscreen presence definitely fits Tony's tragically idealistic journey. The story takes place in 1950s NY and is a retelling of Romeo and Juliet .
    Federal Bureau of Investigation  can question 'anybody' about Kavanaugh

    Federal Bureau of Investigation can question 'anybody' about Kavanaugh

    She said she was able to get away and run into the bathroom after Judge jumped on her and Kavanaugh, knocking them off the bed. Ford said Kavanaugh tried to remove her clothes and held his hand over her mouth to prevent her from screaming.
    Fan Bingbing: China says missing actress fined for tax evasion

    Fan Bingbing: China says missing actress fined for tax evasion

    She said she accepted the punishment meted out by the authorities and will pay the fine. Fan's office has denied ever using such contracts.
  • Teetotal Trump: I'd be a mess as a drinker

    Teetotal Trump: I'd be a mess as a drinker

    Some Republicans fear that pushing ahead with confirmation would alienate women voters, while Democrats seek to capitalise. Flake said over the weekend that he would vote for Kavanaugh unless the FBI finds something in its investigation.
    Spider-Man dev offers to remove 'world's saddest Easter egg'

    Spider-Man dev offers to remove 'world's saddest Easter egg'

    Spider-Man takes top place in the United Kingdom charts followed by Dragon Quest XI and then, still, Grand Theft Auto V. It turns out, after passing their fifth year anniversary in April, Madison. was not still around in September.
    Tesco CEO: Launch Of Jack's 'Nothing To Do With Brexit'

    Tesco CEO: Launch Of Jack's 'Nothing To Do With Brexit'

    British provenance will be a key point of difference for Jack's, with eight out of 10 products grown, reared or made in Britain. Tesco chief executive Dave Lewis said: "Jack Cohen championed value for customers and changed the face of British shopping".

Cristiano Ronaldo sued over alleged rape of Kathryn Mayorga Cristiano Ronaldo sued over alleged rape of Kathryn Mayorga The 33-year-old recently joined the Italian champions in the summer in a deal valued around £100 million. He then pulled her into a bedroom and raped her as she screamed "no, no, no", the lawsuit said.

Jodis Kriti, Roshmi Banik get evicted from Big Boss 12 Jodis Kriti, Roshmi Banik get evicted from Big Boss 12 Karanvir, Somi Khan , Saba Khan , Sreesanth , Dipika and Romil made efforts to bring the couple back together but to no avail. As per the task, one of them was held captive while the other was asked to give up certain things to free their partner.

Oil at 4-year peak, Brent above $85/bbl ahead of Iran sanctions Oil at 4-year peak, Brent above $85/bbl ahead of Iran sanctions Worldwide benchmark Brent crude oil futures were at $85.28 per barrel, up 30 cents (0.4%) from their last close. Five analysts estimated that crude stocks rose about 1.1 million barrels in the week ended September 28.

Queen Letizia attends final of Women's Basketball World Cup Queen Letizia attends final of Women's Basketball World Cup In the third place match between host nation, Spain and Belgium, the Spaniards edged that 67-60 to clinch the bronze medal. The U.S. coach had joked after the semifinal win that she would sit Bird for the gold medal game to keep the record.

Trump Mock's Kavanaugh Accuser's Vague Allegations: 'I Don't Know!' Trump Mock's Kavanaugh Accuser's Vague Allegations: 'I Don't Know!' He describes Ford as a "remarkable profile in courage" while calling the president "a profile in cowardice". With Republicans defending majorities in the House and Senate next month, officials cast Mr.

Americans Can't Opt Out of Today's 'Presidential Alert' Americans Can't Opt Out of Today's 'Presidential Alert' The Integrated Public Alert and Warning System (IPAWS) is created to warn Americans in the event of a national emergency. The Communications Act of 1934 lets the president use private sector communication platforms for emergency messages.

Cubs Lose Against Brewers, Face Must-Win Situation Tonight Cubs Lose Against Brewers, Face Must-Win Situation Tonight Lester (18-6, 3.32 ERA) has been on a roll of late and has won his past three starts and four of his five outings in September. There's also this: Happ has been lights out against the Red Sox, who await the wild-card victor in an AL Division Series.

Central Texas surf resort closed for 'brain-eating amoeba' testing Central Texas surf resort closed for 'brain-eating amoeba' testing The federal agency says only four of the 143 people known to have been infected in the US between 1962 and 2017 have survived. Fabrizio "Fab" Stabile , 29, of Ventnor, N.J., died September 21 - five days after complaining of a severe, sudden headache .

Donald Trump: ‘it’s a very scary time for young men in America’ Donald Trump: ‘it’s a very scary time for young men in America’ Asked by Yahoo News on Tuesday whether he had a message for young women, Trump responded, "Women are doing great". Smyth, two people who Ford said were at the gathering of teenagers where Kavanaugh allegedly assaulted her.

Mourinho blames police for United bus delay Mourinho blames police for United bus delay Our attacking players aren't in their best moments of confidence and individual level. "It will be good for the team if we can beat Newcastle ".

Trump mocks Kavanaugh accuser, claims it's a 'scary time' for men President Trump, as well as his family, have raised fears about the possibility of politically motivated false accusations. It's common for sexual assault victims to remember the attack in great detail, but experience other memory gaps.

Senators Stick to Partisan Lines Over Kavanaugh Nomination Senators Stick to Partisan Lines Over Kavanaugh Nomination The nomination has become a politically explosive issue ahead of November 6 elections, when control of Congress is at stake. The FBI investigation was launched at the urging of Republican Senators Jeff Flake , Susan Collins and Lisa Murkowski.

Lloris back to face Barcelona but quartet ruled out for Tottenham Lloris back to face Barcelona but quartet ruled out for Tottenham Football is not a drama but always it's about being focused, competitive and enjoying playing against the best player in the world".

Cubs-Brewers Set For National League Tiebreaker Cubs-Brewers Set For National League Tiebreaker The Dodgers, meanwhile, will host the Colorado Rockies after the two also ended the season knotted atop the division on Sunday. Lester is no stranger to October baseball, as he's set to make his 22nd postseason start and his second in the Wild Card game.

Trump helped parents hide money on tax returns Trump helped parents hide money on tax returns They revealed Trump received at least $US413 million in today's dollars from when he was a small child through the present day. The paper also alleges that the president "helped his father take improper tax deductions worth millions more".