Wednesday, 19 December, 2018

American, Japanese win Nobel for lifesaving cancer research

Nobel prize laureates James P. Allison left and Tasuku Honjo are shown during the presentation in Stockholm on Oct. 1 AP Nobel prize laureates James P. Allison left and Tasuku Honjo are shown during the presentation in Stockholm on Oct. 1
Johnnie Parks | 01 October, 2018, 17:39

American James Allison and Japanese Tasuku Honjo won the 2018 Nobel Prize for Physiology or Medicine on Monday for game-changing discoveries about how to harness and manipulate the immune system to fight cancer. Lower left: Antibodies (green) against CTLA-4 block the function of the brake leading to activation of T cells and attack on cancer cells.Upper right: PD-1 is another T-cell brake that inhibits T-cell activation. One cancer doctor said "an untold number of lives. have been saved by the science that they pioneered".

"Because this approach targets immune cells rather than specific tumors, it holds great promise to thwart diverse cancers", the Lasker Foundation wrote when it awarded Allison its 2015 Lasker-DeBakey Clinical Medical Research Award.

Allison studied a protein that acts as a brake on the immune system and the potential of releasing that brake. In 1982, while working at The University of Texas System Cancer Center, Allison made a breakthrough discovery - identifying the T-cell antigen receptor, which allows T cells to recognize an unusual protein on the surface of another cell.

Dr. Allison is chair of Immunology and executive director of MD Anderson's Moon Shots Program's Immunotherapy platform.

Today, immunotherapies based on Allison and Honjo's research work especially well for fighting advanced and aggressive tumors. Lanier says he often spent Thanksgiving and Christmas holidays with Allison in the mid-1990s, and remembers Allison talking about the initial experiments that showed him CTLA-4 could fight cancer in mice. "A comment like that makes me happier than any prize", he said.

Thanks to Allison's doggedness, anti-CTLA-4 therapy is now an accepted therapy for cancer and it opened the floodgates for a slew of new immunotherapies, Krummel said.

Krishna Raj Kapoor, wife of Raj Kapoor, dies at 87
A video from the last rites show Taimur Ali Khan's grandmother making her way out of the house with Kareena by her side. Krishna Raj Kapoor took her last breath on October 1, 2018, at the age of 87 after suffering a cardiac arrest.


Judiciary Committee to hold Kavanaugh vote Friday, senators say
But Senator Lindsey Graham, a Republican from SC , hit out at the Democrats following Blasey Ford's testimony. A Republican senator, John Cornyn of Texas, said he "found no reason to find ( Blasey Ford ) not credible".


Watch Kanye West Perform on SNL with Lil Pump & Teyana Taylor
That's a Democratic plan", West said, flanked by SNL cast members and his collaborative musicians Kid Cudi and 070 Shake . West's wife, Kim Kardashian West, warned her million followers that "Tonight's SNL performance is gonna be insane !"


Normally, PD-1 proteins work like sunglasses. Perlmann said the Nobel Committee chose to highlight Allison and Honjo to reflect the basic science that created a new "pillar" of cancer therapy.

Also on Monday, a French photographer at the center of the scandal that led to the unprecedented postponement of the 2018 Nobel Prize in Literature was sentenced to two years in prison for rape.

Checkpoint therapy using PD-1 has proven more effective and positive results are being seen in several types of cancer, including lung cancer, renal cancer, lymphoma and melanoma.

No Nobel Literature Prize is being given this year because the Swedish Academy, the body that choses the literature victor, has been in turmoil after sex abuse and financial scandal allegations.

The winners of this year's physics prize will be announced on Tuesday, followed by the chemistry prize on Wednesday.

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