Saturday, 18 August, 2018

Chemotherapy can be avoided with common breast cancer

Many breast cancer patients can skip chemo big study finds Many breast cancer patients can skip chemo big study finds
Johnnie Parks | 05 June, 2018, 19:43

A new medical study says that 70% of women diagnosed with one of the most common forms of breast cancer might not need chemotherapy treatment.

Trial Assigning IndividuaLized Options for Treatment (Rx), or TAILORx, successfully confirmed the benefit of endocrine therapy alone in patients with early-stage breast cancer who have an Oncotype DX Breast Recurrence Score of 11 to 25.

More than 60,000 women a year in the USA could be affected, according to a lead researcher Dr. Joseph A. Sparano of Montefiore Medical Center in NY, and 70 percent of patients who would be potential candidates for chemo could be spared.

According to the World Cancer Research Fund International, breast cancer is the most common cancer in women worldwide.

"I'd make sure women are educated about the new results especially when they talk to their Oncologist about what additional treatment beyond surgery is needed" said Abraham.

Laszlo Radvanyi, scientific director of the Ontario Institute for Cancer Research, told TheGuardian it was an "unprecedented" result, and could dawn in a completely new age of cancer treatment.

Researchers were keen to stress that more trials on greater numbers of patients will need to be carried out before the therapy could come into wider use.

The test assigned women a score from 0 to 100, based on the likelihood cancer would return within 10 years.

Now cancer scientists across the globe are looking at how this new research - which was published in Nature Medicine today - can be applied to any type of cancer.

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One difference: In women 50 or younger, chemo was associated with a lower risk of cancer recurrence, although the rates of overall survival were similar.

This week, a trial showed that men given just months or weeks to live after being diagnosed with prostate cancer are surviving for more than a year thanks to a breakthrough in immunotherapy treatment. The prospective TAILORx study was created to help to discover whether chemotherapy is beneficial for women with a mid-range recurrence score of 11 to 25, as well as to prospectively confirm that a low recurrence score of 0-10 is associated with a low rate of distant recurrence if patients receive endocrine therapy without adjuvant chemotherapy. But although Mall returned to health soon after her surgery and remains cancer-free today, she said she was haunted by the uncertainty of her decision. Once collected, the cells are armed with cancer-recognizing molecules so that when they are reintroduced into the patient's body they can home in on the tumors and kill them off.

All women like those in the study should get gene testing to guide their care, said Dr. Richard Schilsky, chief medical officer of the oncology society.

"They were sick all the time", she said.

Oncotype DX is becoming more standard.

The results "should have a huge impact on doctors and patients", Albain said.

More than 1,200 people enrolled in the study, the largest clinical trial to date of pembrolizumab as a stand-alone therapy for lung cancer.

This work showed "we are now at the cusp of a major revolution in finally realizing the elusive goal of being able to target the plethora of mutations in cancer through immunotherapy", he wrote.

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