Saturday, 26 May, 2018

The cold - could it become less common?

GettyImages-177347179 Common cold cure on horizon after new drug successfully kills multiple strains of the virus
Johnnie Parks | 15 May, 2018, 21:28

But if we're lucky, that might not be the case for much longer. The researchers have made a molecule that has shown to the ability to block the multiple strains of the most common cold virus, rhinovirus.

We often talk about the common cold like it's one illness caused by one germ, but in reality, a cold can be triggered by nearly 200 different viruses.

The new treatment developed at London's Imperial College blocks the protein, cutting off the infection at an early stage.

But the new approach could be more successful because it does not target the virus directly.

To replicate inside their host, viruses hijack a protein in human cells called N-myristoyltransferase (NMT), which they use to construct a capsid (shell) for protecting their genetic structure.

All strains of the virus need this same human protein to make new copies of themselves, so the molecule should work against all of them.

This hijacking behaviour isn't unique to rhinovirus.

The molecule was initially discovered when searching for a way to take on malaria parasites.

Weather Forecast For The San Francisco Bay Area
The trades are forecast to weaken from today into mid-week, then become breezy once again from Thursday into this weekend. The risk for showers or thunderstorms will return to the forecast later this week with warm and humid conditions.


ZTE Ceases Operations Due To US Ban, Despite Trump Pledge
Weighing on markets was the trade struggle between the United States and China which still shows little sign of a quick resolution.


Putin Drives Truck to Open New Russia-Crimea Bridge
Such a bridge was first proposed under the last Czar Nicholas II before World War I broke out, preventing it going ahead. Today, Russian President Vladimir Putin drove along the Crimean bridge behind the wheel of Kamaz.


Scientists have investigated these kinds of NMT inhibitors before, but they've never previously struck upon this level of potency.

While an uncomfortable nuisance for the vast majority of people, the common cold can be life-threatening for those living with serious illnesses and immune deficiencies.

By inventing a novel way to combine the two, they created a molecule, codenamed IMP-1088, which is more than a hundred times more potent than previous molecules targeting the protein in humans.

"There is a still a long way before this becomes a medicine".

"A drug like this could be extremely beneficial if given early in infection, and we are working on making a version that could be inhaled so that it gets to the lungs quickly", he added.

In addition, there's a chance the compound, if shown to be safe, could end up treating other conditions that also complicated by rhinovirus - such as asthma and cystic fibrosis.

The common cold leads to around 27 million days off work each year in the UK. The results of initial tests are published today in the journal Nature Chemistry.

Recommended

  • Rumour: Retro Studios Working On Star Fox: Grand Prix For Nintendo Switch

    Rumour: Retro Studios Working On Star Fox: Grand Prix For Nintendo Switch

    We don't know whether Retro has been working on Star Fox Grand Prix for the majority of the past four years or not. Fans always make up Nintendo rumours at this time of the year, so we wouldn't take any of this at face value.
    National gas prices on the rise again

    National gas prices on the rise again

    You may have noticed, gas prices are up, hitting levels we haven't seen in nearly three years. Modesto- $3.53/g, up 7.1 cents per gallon from last week's $3.45/g.
    O'Brien hits historic ton as Ireland fight back

    O'Brien hits historic ton as Ireland fight back

    Cricket Ireland have said that one or two Test matches a year will probably be the limit that the Ireland side will play. Abbas in just his sixth Test match took Boyd Rankin and Tyrone Kane's wicket next, completing a five-wicket haul.
  • Agents of SHIELD Season 6 Waits For Summer 2019

    Agents of SHIELD Season 6 Waits For Summer 2019

    Still, don't think the show has been that great this season and wish the group was more involved with the MCU movies. Regardless, fans can breathe a sigh of relief that the series will indeed return, if in a more abbreviated form.
    School board approves union contracts including those for teachers

    School board approves union contracts including those for teachers

    HOLLAND PATENT -Voters in the Holland Patent school district will decide on the district's $34.5 million proposed 2018-19 budget. Voting will be held Tuesday between noon and 9 p.m.at the Vernon Town Offices, Verona Fire Station, and Sherrill Court Facility.
    Mercedes explains stall in Lewis Hamilton contract talks

    Mercedes explains stall in Lewis Hamilton contract talks

    F1 bosses held talks with Silverstone over staging the sport's 1,000th championship race there next year. We could just as easily go to the next race and struggle getting our tyres working and be nowhere.
  • 'Bohemian Rhapsody' gets a teaser trailer

    'Bohemian Rhapsody' gets a teaser trailer

    What did you think of this trailer, will you be checking out this film? Bohemian Rhapsody is released on November 2, 2018. It's nearly as if this feels teaser makes Bohemian Rhapsody feel more like a cheap, made-for-TV movie than anything else.
    American Airlines updates support animal policy

    American Airlines updates support animal policy

    American Airlines joins its competitors in clamping down on passengers travelling with emotional support animals. If a hedgehog, snake, or goat is your support animal, American Airlines is not the carrier for you.
    Vodafone boss Vittorio Colao to step down

    Vodafone boss Vittorio Colao to step down

    Telecommunication giant Vodafone's CEO Vittorio Colao stepped down from his position on Tuesday. On the face of it this appears to be sensible timing for change.
  • Second British rugby player dies in Sri Lanka

    Second British rugby player dies in Sri Lanka

    The club issued a statement which said: "The Howard and Baty families have requested that their right to privacy is respected". A British rugby player has died in Sri Lanka after returning from a night out - with a team-mate left in critical condition.
    Retailer Gap apologises for T-shirts with 'incorrect' map of China

    Retailer Gap apologises for T-shirts with 'incorrect' map of China

    The Gap's website originally listed the T-shirts as being available in Canada, Japan, Paris, China, San Francisco and NY . It also added that it would implement more rigorous reviews to ensure the same thing would not happen again.
    Project Maven: Google employees resign over controversial U.S.  military AI programme

    Project Maven: Google employees resign over controversial U.S. military AI programme

    Nearly 4,000 employees signed an internal letter demanding Google pull out from the project, according to Bloomberg . Project Maven looks to help the United States military assess drone footage quickly using AI and machine learning.

YouTube Is Testing New Incognito Mode for Android YouTube Is Testing New Incognito Mode for Android The YouTube TV app has been reportedly added with a new feature that allows you to instruct your choice of shows. It's a toggleable option in the settings page, and will present itself as a floating button on-screen.

The Home Depot (HD) Gains Outperform Rating from Analysts at Wells Fargo The Home Depot (HD) Gains Outperform Rating from Analysts at Wells Fargo The ratio is negative due to HD positioning: 51 sold and 662 reduced. 501 rose positions while 164 funds bought positions. Denali Advisors LLC acquired a new stake in The Home Depot during the fourth quarter worth about $133,000. (NYSE:HD).

Nintendo Announces Details for Mario Tennis Aces Pre-Launch Online Tournament Demo Nintendo Announces Details for Mario Tennis Aces Pre-Launch Online Tournament Demo For our thoughts on Mario's last astroturf appearance, check out IGN's review of Mario Tennis: Ultra Smash . The playable roster will consist of four characters that include Mario , Peach, Yoshi, and Bowser.

Driver: Tesla's Autopilot engaged during Utah crash Driver: Tesla's Autopilot engaged during Utah crash Police in Utah are looking into a collision involving a Tesla electric auto that hit a fire department vehicle over the weekend. Two people died in that incident, although the NTSB does not believe that Tesla's semi-autonomous system was to blame.

Microsoft Goes Back to the Drawing Board with the Surface Hub 2 Microsoft Goes Back to the Drawing Board with the Surface Hub 2 Despite the rumours and speculations, Microsoft remains totally committed to the Surface Hub product line. Microsoft has announced a "more affordable" Surface Hub 2 will offer a 4K+ 50.5-in multitouch display.

70 officers escort slain officer's son as he returns to school 70 officers escort slain officer's son as he returns to school Rob Pitts was a 16-year veteran of the department, and Dakota wore his dad's police badge around his neck to school. A t-shirt company has raised nearly $15,000 in Rob Pitts' name to help the department buy a new police dog.

Government Officials Drive The George Soros Foundation Out Of Hungary Government Officials Drive The George Soros Foundation Out Of Hungary A magazine owned by an Orban ally later published the names of hundreds of NGO staff, academics, and journalists it said were in the pay of Soros.

Scientists say they have transferred memories between sea slugs, via injection Scientists say they have transferred memories between sea slugs, via injection A group of untrained snails received RNA from the trained group and the second group received RNA from an untrained group. Then underwent RNA Guinea rabbits with nerve nodes in the body other slugs, which is not affected by the shock.

Germany coach Joachim Low agrees contract extension to 2022 Germany coach Joachim Low agrees contract extension to 2022 The Borussia Dortmund start scored in extra time against Argentina in 2014 to give Germany its fourth World Cup . What do you make of Low's Germany squad? "We did not need long to get a conclusion", Grindel said.

Del Toro will helm a horror series for Netflix Del Toro will helm a horror series for Netflix The project marks del Toro's first live-action program for Netflix , which is home to his animated show Trollhunters . Netflix also picked up anthology horror series Slasher a year ago from defunct Canadian channel Chiller.

NASA plans autonomous helicopters to land on Mars in 2020 NASA plans autonomous helicopters to land on Mars in 2020 NASA hopes that the helicopter will fly around 10 feet high and then stay hovering stable for 30 seconds for its firs test flight. Mars is several light-minutes away, so it's impossible to control the helicopter's flight path or landing in real time.

David Moyes 'likely to leave West Ham United' David Moyes 'likely to leave West Ham United' I go back to when I took over and was trying to get results by hook or by crook, there was a lot more structure today". We'll wait and see when we meet up". "I'd like to change things but maybe not everyone is happy with change".

Malaysia's new leader indicates anti-fake news law to stay Malaysia's new leader indicates anti-fake news law to stay The new prime minister also said jailed opposition leader and coalition partner Anwar Ibrahim would be freed on Wednesday. Mahathir, 92 was sworn in as the leader on Thursday, making him the world's oldest democratically elected leader.

Steven Gerrard set to unveil his first signing as Rangers manager Steven Gerrard set to unveil his first signing as Rangers manager Rangers supporters will be hoping Arfield is the first of many signings in a much-needed squad overhaul at the club. Arfield said: "As soon as the interest came in, it was something I wanted to go for".

Xiaomi launching new smartphone on June 7, will it be Redmi S2? Xiaomi launching new smartphone on June 7, will it be Redmi S2? Only the Redmi Note 5 gets some sort of scratch protection with an unspecified version of Gorilla Glass coating on the display. The most attractive mid-range smartphone from Xiaomi , the double curved antenna line on this device is out of the world.