Friday, 25 May, 2018

Food protein linked to cancer spread

Metastatic Breast Cancer cured in Future Discovery in understanding the spread of breast cancer could lead to new treatments to slow metastasis
Johnnie Parks | 08 February, 2018, 10:22

The result: Cancer in mice on the low asparagine diet spread much more slowly.

Researchers have discovered a link between the spread of cancer with an amino acid found in a number of different foods including asparagus.

Foods rich in the amino acid asparagine include dairy products, beef, poultry, eggs, fish, asparagus, beans, nuts, seeds, soy and whole grains.

Asparagine is an amino acid - the building blocks that cells use to make proteins.

As per the study in Cancer Epidemiology, Biomarkers & Prevention in May 2017, the five year comparative survival rate for patients with metastatic breast cancer magnified between 1992 to 1994 and 2005 to 2012, increasing from 18 percent to 36 percent.

A team of global cancer researchers from the UK, US and Canada studied the impact of asparagine in triple-negative breast cancer cells, which grow and spread faster than most other types of cancer cells.

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'This finding adds vital information to our understanding of how we can stop cancer spreading - the main reason patients die from their disease'. But the researchers are still considering a human trial to see if the diet can really help.

The researchers also found that metastasis was greatly limited by reducing asparagine synthetase. When this takes place the disease has already reached stage 4 called the metastatic cancer.

United Kingdom researchers have discovered a nutrient in everyday foods can determine a cancer's growth and expansion.

"This is interesting research looking at how cutting off the supply of nutrients essential to cancer's spread could help restrain tumours".

Lead scientist Professor Greg Hannon, from the Cancer Research UK Cambridge Institute, said: "Our work has pinpointed one of the key mechanisms that promotes the ability of breast cancer cells to spread". The animals had triple-negative breast cancer, which grows and spreads faster than other types and is notoriously hard to treat. They do know that not all cancer patients would benefit from this treatment. The Kras gene activation is common in patients with pancreatic cancer. "At the moment, there is no evidence that restricting certain foods can help fight cancer, so it's important for patients to speak to their doctor before making any changes to their diet while having treatment".

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